Full text is available at the source.
Abstract
Circadian rhythm disruption from night-shift work is associated with elevated blood pressure in both mice and humans.
- Simulated night shift work in mice results in increased blood pressure and mitochondrial dysfunction.
- Circadian gene dysregulation, such as alterations in PER1 and BMAL1, occurs in response to night shift work.
- In human night shift workers, longer exposure duration correlates with higher systolic and diastolic blood pressure.
- Dysregulation of circadian and mitochondrial markers is observed alongside increased blood pressure in humans.
- Mitochondrial dysfunction may be a key mechanism linking circadian disruption to elevated blood pressure.
Simplified
Circadian Biology