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Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models
Mitochondrial Problems May Link Night Shift Work’s Disrupted Body Clock to Higher Blood Pressure in Humans and Mice
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Abstract
Circadian rhythm disruption from night-shift work is associated with elevated blood pressure in both mice and humans.
- Simulated night shift work in mice results in increased blood pressure and mitochondrial dysfunction.
- Circadian gene dysregulation, such as alterations in PER1 and BMAL1, occurs in response to night shift work.
- In human night shift workers, longer exposure duration correlates with higher systolic and diastolic blood pressure.
- Dysregulation of circadian and mitochondrial markers is observed alongside increased blood pressure in humans.
- Mitochondrial dysfunction may be a key mechanism linking circadian disruption to elevated blood pressure.
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