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Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay
Morning and evening internal clocks separately influence movement control areas through a specific dopamine pathway
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Abstract
Ring neurons of the ellipsoid body exhibit spontaneous morning and evening neural activity peaks that correspond with locomotor activity.
- Two types of circadian neural oscillators in Drosophila, morning (M) and evening (E) cells, show distinct peaks in neural activity.
- The peaks of activity from M and E cells activate ring neurons independently.
- Identified dopaminergic neurons, PPM3, regulate the activity of ring neurons and are co-active with them.
- These findings indicate a specific pathway where different circadian oscillators control a common pre-motor center.
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