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The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude
The mouse Clock mutation lowers the strength of daily rhythms and increases how strongly timing cues reset them
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Abstract
Heterozygous Clock/+ mice show high-amplitude phase-resetting responses to light compared to wild-type mice.
- Clock/+ mice exhibit Type 0 phase-resetting responses, while wild-type mice display Type 1 responses.
- The mutation does not affect the acute light induction of Per1 and Per2 genes in the suprachiasmatic nuclei.
- Circadian rhythms of Per gene expression are significantly reduced in both Clock homozygous and heterozygous mutants.
- PER2::LUCIFERASE expression in explant cultures from Clock heterozygotes shows reduced amplitude.
- Phase-response curves to changes in culture medium are Type 0 for Clock heterozygotes and Type 1 for wild types.
- A model suggests that the Clock mutation reduces the amplitude of the circadian pacemaker in the suprachiasmatic nuclei.
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