Multiple early factors anticipate post-acute COVID-19 sequelae

Feb 26, 2022Cell

Several early signs may predict long-term symptoms after COVID-19

AI simplified

Long Covid on OpenScience ↗PubMed ↗DOI ↗

Abstract

Four quantifiable risk factors for post-acute sequelae of COVID-19 (PASC) were identified in 309 patients at diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, and specific auto-antibodies.

Patients with gastrointestinal PASC exhibited unique dynamics in SARS-CoV-2-specific and CMV-specific CD8T cells during recovery.
Immunological signatures associated with symptoms indicated a polarization of immunity into four distinct endotypes.
The relationship between PASC-associated immunological factors and patient condition appeared to decrease over time.
Early measurement of PASC risk factors at diagnosis may enhance understanding of chronic conditions following COVID-19.

AI simplified

Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data and patient-reported symptoms. We resolved four PASC-anticipating risk factors at the time of initial COVID-19 diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, and specific auto-antibodies. In patients with gastrointestinal PASC, SARS-CoV-2-specific and CMV-specific CD8T cells exhibited unique dynamics during recovery from COVID-19. Analysis of symptom-associated immunological signatures revealed coordinated immunity polarization into four endotypes, exhibiting divergent acute severity and PASC. We find that immunological associations between PASC factors diminish over time, leading to distinct convalescent immune states. Detectability of most PASC factors at COVID-19 diagnosis emphasizes the importance of early disease measurements for understanding emergent chronic conditions and suggests PASC treatment strategies. +

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text (XML) ↗View full text ↗

Multiple early factors anticipate post-acute COVID-19 sequelae

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the long covid brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the long covid brief