JAMA network open

Chronic Fatigue Syndrome Following COVID-19 Infection

Updated

Abstract

A 3% to 4% prevalence of ME/CFS-like illness was found after acute SARS-CoV-2 infection over 12 months of follow-up.

  • No significant changes in the prevalence of ME/CFS-like illness were observed from 3 to 12 months after acute infection.
  • The prevalence of ME/CFS-like symptoms was similar between COVID-19-positive (2.8%-3.7%) and COVID-19-negative (3.1%-4.5%) groups.
  • Statistical analyses indicated no significant difference in the odds of ME/CFS-like illness between individuals with and without SARS-CoV-2 infection.
  • Survey completion rates varied, ranging from 38.7% to 76.3%, and decreased over the follow-up period.

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Funding

Competing interests

Conflict of Interest Disclosures: Dr Wisk reported receiving grants from the Centers for Disease Control and Prevention (CDC) and US Department of Health and Human Services during the conduct of the study. Dr Lavretsky reported receiving grants from the National Center for Complementary and Integrative Health, National Institute of Mental Health, US Department of Defense, and Patient-Centered Outcomes Research Institute (PCORI) outside the submitted work and royalties for books published by Oxford University Press and Johns Hopkins University Press. Dr Montoy reported receiving grants from the CDC’s National Center for Immunization and Respiratory Diseases (NCIRD) during the conduct of the study and from the CDC outside the submitted work. Dr Gottlieb reported receiving grants from the CDC during the conduct of the study. Dr Rising reported receiving grants from the CDC during the conduct of the study and from the National Institutes of Health outside the submitted work. Dr Gentile reported receiving grants from the CDC during the conduct of the study and being the primary care medical director of the COVID Aftercare, Recovery, and Support (CAReS) Clinic at the University of Washington. Dr Venkatesh reported receiving grants from the CDC during the conduct of the study and from the Society for Academic Emergency Medicine Foundation outside the submitted work. Dr Huebinger reported receiving grants from the CDC during the conduct of the study. Dr Idris reported receiving grants from the CDC during the conduct of the study. Dr Spatz reported receiving grant funding from the CDC; US Food and Drug Administration to support projects within the Yale University–Mayo Clinic Center of Excellence in Regulatory Science and Innovation; National Heart, Lung, and Blood Institute; and PCORI. Dr Stephens reported receiving grants from the CDC during the conduct of the study. Dr Weinstein reported receiving grants from the CDC during the conduct of the study. Dr Elmore reported receiving grants from the CDC during the conduct of the study and serving as editor-in-chief of adult primary care for UpToDate and as director of the National Clinician Scholars Program at the University of California, Los Angeles. No other disclosures were reported.
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