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Spontaneous contractions of myometrium from humans, non‐human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro
Natural muscle contractions in the womb of humans, primates, and rodents respond to drugs blocking oxytocin receptors in the lab
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Abstract
L-371,257 and atosiban significantly inhibited spontaneous activity of human myometrium in a concentration-related manner (P < 0.05).
- Oxytocin receptor antagonists may influence spontaneous contractions of myometrium from humans, non-human primates, and rodents in vitro.
- The inhibition of spontaneous contractions was more pronounced with L-371,257 compared to atosiban.
- Spontaneous contractions in myometrium from non-pregnant rats and marmosets were also inhibited by L-371,257.
- Spontaneous contractions may depend on oxytocin receptor activity in the tested species.
- L-371,257 and atosiban may act as inverse agonists, suggesting potential use as tocolytics.
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