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Differing In Vitro Potencies of Tocolytics and Progesterone in Myometrium From Singleton and Twin Pregnancies
Different Strengths of Labor-Preventing Drugs and Progesterone on Uterine Muscle from Single and Twin Pregnancies
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Abstract
Both indomethacin and progesterone require greater concentrations to effectively inhibit oxytocin-induced contractions in twin pregnancies compared to singletons.
- All tested agents showed a concentration-dependent relaxant effect on myometrial contractions.
- No significant differences were found in relaxant effects between singleton and twin pregnancies for progesterone or indomethacin on spontaneous contractions.
- Under oxytocin stimulation, indomethacin and progesterone displayed significantly shifted concentration-response curves for both amplitude and activity integral.
- Twin myometrium exhibited significantly greater concentration-response curves for progesterone (P < .05) and indomethacin (P < .001) compared to singleton myometrium.
- These findings suggest that the pharmacologic responses of myometrial tissue may differ between singleton and twin pregnancies.
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