Effects of oxytocin receptor antagonist atosiban on pregnant myometrium in vitro

Atosiban inhibited oxytocin-induced contractions by more than 50% at concentrations as low as 1 microg/mL.

• Inhibition of contraction activity was observed with increasing doses of atosiban.
• The effects were measured by analyzing contraction frequency, amplitude, and area under the force-time curve.
• Atosiban's highest concentrations resulted in contraction activity lower than baseline spontaneous activity.
• The findings suggest a potential role for atosiban in managing contractions during pregnancy.
• The study focused on myometrial strips obtained from healthy pregnant women undergoing elective cesareans.

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