Nanomedicine (London, England)

New nanomaterial methods for delivering treatments directly to the brain in glioblastoma therapy

Updated

Abstract

Nanomaterial-based brain-targeted delivery systems may enhance therapeutic efficacy for glioblastoma treatment.

  • Glioblastoma is associated with high morbidity and mortality due to challenges like the blood-brain barrier and blood-brain tumor barrier.
  • Conventional drugs often face limitations such as poor penetration of the brain barrier, short half-lives, and low bioavailability.
  • Innovative nanoparticle-mediated strategies are explored for improving drug transport kinetics in glioblastoma treatment.
  • Biomimetic nanoparticles offer unique advantages that could facilitate more effective delivery of therapeutic agents.
  • Current challenges and future research directions in this field may lead to better maximization of therapeutic effects for gene drugs or chemotherapeutic agents.

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Full Text

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Funding

Competing interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
PubMed

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