Brain GLP1R helps liraglutide reduce appetite but not blood sugar

Liraglutide treatment lowered glucose levels in mice lacking GLP1 receptors in the brain and visceral nerves.

• Both glucose levels and body weight are regulated by the brain through GLP1 receptors.
• Mice with specific deletions of GLP1 receptors in neurons or visceral nerves showed no change in body weight or food intake with liraglutide treatment.
• Liraglutide effectively reduced glucose levels in chow- and high-fat-fed mice, regardless of GLP1 receptor presence in the CNS or visceral nerves.
• Neuronal GLP1 receptors are associated with the body weight and appetite-suppressing effects of liraglutide.
• GLP1 receptors in the brain are not necessary for the glucose-lowering effects of liraglutide.

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