Full text is available at the source.
NOD1/NF-κB signaling pathway inhibited by sodium butyrate in the mammary gland of lactating goats during sub-acute ruminal acidosis
Sodium butyrate reduces inflammation signaling in the milk-producing glands of goats during mild rumen acidosis
AI simplified
Abstract
A pH value < 5.8 sustained for more than 3 hours per day confirms subacute ruminal acidosis (SARA) in goats on a high-concentrate diet.
- A high-concentrate diet may induce SARA in mid-lactating goats by lowering rumen pH.
- Goats receiving the high-concentrate diet with sodium butyrate showed lower levels of lipopolysaccharides (LPS) in their blood compared to those on the regular high-concentrate diet.
- The group treated with sodium butyrate had significantly reduced levels of proinflammatory cytokines in their blood.
- Decreased expression of immune response-related genes (NOD1, IKβ, and NF-κB) was observed in the mammary glands of goats treated with sodium butyrate.
- Oral sodium butyrate supplementation may inhibit the NOD1/NF-κB inflammatory pathway linked to mammary inflammation.
AI simplified