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Abstract
Oral supplementation with stachyose reverses insulin resistance, hyperglycemia, and dyslipidemia in overweight mice.
- Stachyose improves metabolism by enhancing insulin sensitivity and reducing blood sugar levels.
- Supplementation is associated with improved fat tissue structure and reduced liver fat accumulation.
- RNA sequencing and protein analysis show that stachyose restores important signaling pathways in metabolic organs.
- Stachyose increases the secretion of a hormone called GLP-1 from specific intestinal cells through a particular signaling pathway.
- Blocking the GLP-1 receptor negates the metabolic benefits of stachyose, indicating its key role in these effects.
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