Non-daily BMAL1-YAP activity increases ongoing inflammation in aged skin

Aged murine skin exhibits a shift in BMAL1-YAP cooperation that enhances inflammation-related gene expression.

• Aging in the skin is associated with increased low-grade inflammation and impaired barrier function.
• BMAL1 and YAP cooperate at specific genomic sites to regulate gene expression related to skin health.
• In aged skin, this cooperation shifts to promote inflammation-related gene transcription.
• The cooperation is partially regulated by the NF-κB pathway.
• IL-17 signaling in aged skin activates YAP independently of the Hippo pathway.
• These findings suggest a transcriptional mechanism linking aging and inflammation in the skin.

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