Diabetes, obesity & metabolism

Weight Changes and Treatments After Stopping Semaglutide or Tirzepatide in Medical Care

Updated

Abstract

In a cohort of 7938 patients, 19.6% restarted semaglutide or tirzepatide after discontinuation.

  • During the first year after discontinuation, 35.2% of patients received an alternative obesity treatment.
  • Weight change from baseline to medication discontinuation averaged -8.4% for obesity treatment and -4.4% for diabetes treatment.
  • One year after discontinuation, weight change was relatively small, averaging 0.5% for obesity treatment and -1.3% for diabetes treatment.
  • There was considerable variability in individual weight changes post-discontinuation.

Simplified

Full Text

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Funding

Competing interests

Dr. Hamlet Gasoyan reported receiving grant funding from the National Cancer Institute outside the submitted work. Dr. Christopher B. Boyer reports consulting fees from Janssen Pharmaceuticals outside the submitted work. Dr. W. Scott Butsch is currently employed by Novo Nordisk A/S; he also reported advisory board fees from Eli Lilly, Boehringer Ingelheim and Abbott and research funding from Eli Lilly and Co outside the submitted work. Dr. Ali Aminian reported receiving research grants from Amgen, Ethicon and Medtronic outside the submitted work. He serves as a consultant for Amylyx, Eli Lilly, Ethicon and Medtronic. Dr. Marcio L. Griebeler reported research funding from Novo Nordisk A/S outside the submitted work. Dr. Michael B. Rothberg reported receiving consulting fees from the Blue Cross Blue Shield Association outside the submitted work. The other authors declare no conflicts of interest.
PubMed

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