Oral and intestinal dysbiosis in Parkinson's disease

Dysbiosis is associated with both motor and non-motor symptoms of Parkinson's disease.

• The microbiota plays a crucial role in the body's physiological functions and is linked to the pathogenesis of Parkinson's disease.
• In animal models, dysbiosis promotes symptoms in genetically susceptible individuals, indicating it may act as a risk factor.
• Dysbiosis induces complex metabolic changes, leading to increased intestinal permeability and inflammation.
• The presence of dysbiosis is linked to the production of bacterial proteins that may contribute to the aggregation of α-synuclein.
• Dysbiosis is associated with a decrease in beneficial bacteria that produce short-chain fatty acids, which have protective roles.
• Interventions targeting gut microbiota, such as dietary changes and probiotics, could potentially influence the progression of Parkinson's disease.

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