Diabetes, obesity & metabolism

Real-world use of oral semaglutide in adults with type 2 diabetes in Spain

Updated

Abstract

Participants experienced an estimated average change in glycated hemoglobin (HbA) of -1.4%-points after oral semaglutide treatment.

  • A total of 430 participants completed the study, with 392 on treatment at the end of the study.
  • Body weight decreased by an estimated average of -6.8% following treatment.
  • In participants using SGLT2 inhibitors, the average HbA change was -1.8%-points, compared to -1.2%-points in those not using SGLT2 inhibitors.
  • Participants with type 2 diabetes duration of 5 years or less experienced a greater average HbA change than those with longer durations.
  • At the end of the study, 77.4% of participants achieved an HbA level below 7%, and 33.3% had both a ≥1%-point reduction in HbA and a ≥5% reduction in body weight.
  • Treatment satisfaction improved, and no new safety concerns were reported.

Simplified

Key numbers

-1.4%-points
HbA Reduction
Change in HbA from baseline to end of study.
-6.8%
Body Weight Reduction
Change in body weight from baseline to end of study.
4.7 points
Treatment Satisfaction Improvement
Change in treatment satisfaction score at end of study.

Full Text

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Funding

Competing interests

The authors disclose the following competing interests: Elías Delgado Álvarez has received unrestricted research support from AstraZeneca, Novo Nordisk, Sanofi, Pfizer, and Roche and has received consulting fees and/or honoraria for membership on advisory boards and speakers bureaus from AstraZeneca, Novo Nordisk, Eli Lilly, Sanofi, GlaxoSmithKline, Pfizer, Almirall, Novartis, Abbott Laboratories, Esteve, and Merck Sharp & Dohme. Cristóbal Morales Portillo has collaborated on clinical studies with Novo Nordisk, Sanofi, AstraZeneca, Pfizer, Eli Lilly, Merck, Lexicon, Hanmi, Janssen, Boehringer Ingelheim, Takeda, Roche, and Theracos and has served on advisory boards for Novo Nordisk, Eli Lilly, MSD, Boehringer Ingelheim, AstraZeneca, Sanofi, and Abbot and has received speaker fees from Sanofi, Novo Nordisk, AstraZeneca, Roche, Eli Lilly, Boehringer Ingelheim, MSD, Ferrer, Janssen, and Abbot. Cristina Abreu Padín has received research support from Sanofi, Novo Nordisk, Boehringer Ingelheim and Eli Lilly and has acted as a speaker for Sanofi, Novo Nordisk, Boehringer Ingelheim, AstraZeneca and Bristol‐Myers Squibb. Alberto Aliaga Verdugo has received research support from AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, Eli Lilly, Gan & Lee, Janssen, Kowa, Lexicon, MSD, Novo Nordisk, Pfizer, and Sanofi and has received honoraria for membership on advisory boards and speakers bureaus from AstraZeneca, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, and Sanofi. Ana Piera Carbonell has received fees for participation in presentations, talks, courses, conferences, or publications from Novo Nordisk, Novartis, MSD, Ferrer, Bayer, Sanofi‐Aventis, AstraZeneca, Esteve, Boehringer Ingelheim, and Mylan. Aída Cadenas González has received support for training, research, or outreach from GSK, Boehringer Ingelheim, Menarini, Janssen, Novo Nordisk, Pfizer, Esteve, Sanofi, Eli Lilly, Viatris, Faes, Alter, AstraZeneca, MSD, Fresenius, Rovi, Mundipharma, Daiichi Sankyo, Novartis, and Amarin. Jaime Amor Valero is an employee of Novo Nordisk Pharma SA. Verónica González López is an employee of Novo Nordisk Pharma SA. Christina Louise Rasmussen is an employee of Novo Nordisk A/S. Stine Hedegaard Scheuer is an employee of Novo Nordisk A/S. Diego Bellido Guerrero has received unrestricted research support from Novo Nordisk, Sanofi, Pfizer, Nestle HC, Persan Pharma, Abbott Laboratories and Eli Lilly and has received consulting fees and/or honoraria for membership on advisory boards and speakers bureaus from Novo Nordisk, Sanofi, Abbott Laboratories, and Eli Lilly.
PubMed

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