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Common oxytocin receptor gene polymorphisms and the risk for preterm birth.
Common variations in the oxytocin receptor gene and the risk of early birth
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Abstract
The haplotype combination of three specific oxytocin receptor gene polymorphisms is associated with a 3.2-fold increased risk of preterm birth.
- Four common oxytocin receptor gene polymorphisms were evaluated in 200 women, including those with preterm birth and healthy controls.
- No individual polymorphism was linked to preterm birth.
- A specific haplotype combination involving the A allele of rs2254298, the C allele of rs2228485, and the G allele of rs237911 was associated with increased risk.
- The odds ratio for this haplotype and preterm birth was 3.2, indicating potential significance.
- Further studies are needed to explore the role of these gene polymorphisms in relation to preterm birth.
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