Psychiatry research

Participant diversity in psychedelic therapy trials: a systematic review

Updated

Abstract

A total of 1,034 participants were included in 21 randomized controlled trials of psychedelic-assisted therapies.

  • Gender was reported in 100% of the studies, while race or ethnicity was reported in 76%.
  • Socioeconomic status was reported sometimes (57%), but sexual orientation (9.5%) and immigration status (4.8%) were rarely noted.
  • No studies reported on gender identity.
  • Black/African-American participants (2.2%) and Hispanic/Latino participants (7.2%) were significantly underrepresented compared to their population proportions.
  • MDMA trials included more diverse participant samples than psilocybin trials.
  • Analyses of treatment effects based on demographic variables were virtually nonexistent.

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Full Text

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Funding

Competing interests

Declaration of competing interest Dr. Woolley reported grants from Filament Health and Usona Institute; nonfinancial support (drug supply program) from Filament Health and Usona Institute; being a Department of Justice expert witness; and being a paid consultant for Magdalena Biosciences, Arcadia Medicine, Reunion Neurosciences, Silo Pharma, Empyrean Neuroscience, Gilgamesh Pharma, Alvarius, and the Alexander Shulgin Research Institute. No other disclosures were reported.
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