Nature neuroscience

Daily activity in fruit flies is influenced by light signals controlled by PDF and cryptochrome

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The evening circadian oscillator in Drosophila is critical for maintaining diurnal activity at dusk.

  • The lateral neurons evening oscillator (LN-EO) synchronizes to light-dark cycles via cryptochrome or the visual system.
  • Flies lacking pigment-dispersing factor (PDF) or its receptor lost evening activity and showed altered PER oscillations.
  • Normal PER cycling and evening activity depend on PDF secretion from large ventral lateral neurons.
  • The results suggest that the LN-EO integrates light signals and PDF signaling to regulate Drosophila's daily behavior.
  • These findings indicate a new role for PDF that is independent of traditional circadian clock mechanisms.

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