Peripheral circadian oscillators and their rhythmic regulation

Circadian rhythms, which are controlled by biological clocks, are found in most organisms, including mammals where they are regulated by the suprachiasmatic nucleus (SCN).

• Circadian oscillators exist in various organs and tissues, but these peripheral oscillators may not be self-sustaining.
• In vitro studies show that peripheral oscillations diminish after a few cycles.
• The molecular structure of the circadian clocks in the SCN and peripheral tissues is largely similar.
• The SCN acts as the master pacemaker, coordinating the timing of peripheral oscillators to synchronize bodily functions.
• Mechanisms of SCN control over peripheral oscillators are beginning to be understood.

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