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A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival
A PERK and miR-211 pathway reduces daily rhythm regulators and protein production to help cancer cells survive
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Abstract
UPR activation induces a 10 h phase shift in circadian oscillations through the induction of miR-211.
- The unfolded protein response (UPR) influences the circadian clock by affecting core regulators Bmal1 and Clock.
- miR-211, which is induced by UPR activation, suppresses both Bmal1 and Clock through different mechanisms.
- Suppression of Bmal1 and Clock alters the expression of certain circadian genes.
- Repression of Bmal1 is crucial for UPR-mediated inhibition of protein synthesis and helps cells adapt to endoplasmic reticulum stress.
- In Burkitt's lymphoma, c-Myc-dependent UPR activation suppresses Bmal1, which may contribute to tumour progression.
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