Developmental cell

Peroxisomes may play a key role in intestine healing after long COVID

Updated

Abstract

Intestinal SARS-CoV-2 reservoirs disrupt VLCFA-mediated peroxisome signaling critical for epithelial repair in Long COVID patients.

  • Long COVID is linked to ongoing gastrointestinal dysfunction.
  • Intestinal reservoirs of SARS-CoV-2 may interfere with signaling pathways necessary for healing the gut lining.
  • Research included patient studies as well as models in fruit flies and mammals to uncover the underlying mechanisms.
  • FDA-approved peroxisome activators have been identified as potential treatments for this condition.

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