Physical Exercise Restores Microvascular Function in Obese Rats with Metabolic Syndrome

Exercise training increased maximal oxygen uptake to 69 ± 3 mL/kg per min in obese rats with metabolic syndrome.

• Exercise training improved exercise tolerance to 30 ± 1 min compared to 16 ± 1 min in sedentary animals.
• Significant reductions in retroperitoneal fat (0.03 ± 0.00 vs. 0.05 ± 0.00 gram/gram) and epididymal fat (0.01 ± 0.00 vs. 0.02 ± 0.00 gram/gram) were observed in the trained group.
• Systolic blood pressure decreased to 127 ± 2 mmHg in the trained group compared to 150 ± 2 mmHg in sedentary animals.
• Fasting plasma glucose levels were lower in the trained group (5.0 ± 0.1 mmol/L) compared to sedentary animals (6.4 ± 0.2 mmol/L).
• The number of spontaneously perfused capillaries in skeletal muscle increased to 252 ± 9 capillaries/mm² in the trained group compared to 207 ± 9 capillaries/mm² in sedentary animals.

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