Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet

Moderate exercise training prevented 80% of the increase in fat pads caused by a high-fat diet in rats.

• High-fat diet (HFD) led to a 75% increase in body fat stores and a 30% reduction in food intake.
• Exercise training increased soleus muscle mass by 24% in normal diet animals.
• HFD caused a hyper-response to glucose injection, which was reduced by 50% through exercise.
• Blood pressure increased due to HFD, but exercise's beneficial effects on blood pressure were inhibited by the diet.
• HFD increased vagal activity by 65%, which was blocked by exercise.
• HFD diminished sympathetic activity and negated the positive effects of exercise on sympathetic responses.

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