We examined whether carbohydrate-protein ingestion influences muscle glycogen metabolism during short-term recovery from exhaustive treadmill running and subsequent exercise. Six endurance-trained individuals underwent two trials in a randomized double-blind design, each involving an initial run-to-exhaustion at 70% VO(Run-1) followed by 4-h recovery (REC) and subsequent run-to-exhaustion at 70% VO(Run-2). Carbohydrate-protein (CHO-P; 0.8 g carbohydrate·kg body mass [BM]·hplus 0.4 g protein·kg BM·h) or isocaloric carbohydrate (CHO; 1.2 g carbohydrate·kg BM·h) beverages were ingested at 30-min intervals during recovery. Muscle biopsies were taken upon cessation of Run-1, postrecovery and fatigue in Run-2. Time-to-exhaustion in Run-1 was similar with CHO and CHO-P (81 ± 17 and 84 ± 19 min, respectively). Muscle glycogen concentrations were similar between treatments after Run-1 (99 ± 3 mmol·kg dry mass [dm]). During REC, muscle glycogen concentrations increased to 252 ± 45 mmol·kg dmin CHO and 266 ± 30 mmol·kg dmin CHO-P (p = .44). Muscle glycogen degradation during Run-2 was similar between trials (3.3 ± 1.4 versus 3.5 ± 1.9 mmol·kg dm·minin CHO and CHO-P, respectively) and no differences were observed at the respective points of exhaustion (93 ± 21 versus 100 ± 11 mmol·kg dm; CHO and CHO-P, respectively). Similarly, time-to-exhaustion was not different between treatments in Run-2 (51 ± 13 and 49 ± 15 min in CHO and CHO-P, respectively). Carbohydrate-protein ingestion equally accelerates muscle glycogen resynthesis during short-term recovery from exhaustive running as when 1.2 g carbohydrate·kg BM·hare ingested. The addition of protein did not alter muscle glycogen utilization or time to fatigue during repeated exhaustive running. 2max2max -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1
