Post-transcriptional control in the body’s internal clock system

Circadian clocks regulate a significant portion of the genome to synchronize physiology and behavior with environmental cues.

• The circadian clock functions as a self-sustained oscillator, primarily driven by feedback loops and modifications of clock proteins.
• Regulation at the RNA level may significantly influence the circadian transcriptome and proteome.
• RNA-binding proteins are involved in modulating the timing of pre-mRNA processing events, affecting rhythmic expression.
• MicroRNAs could play a role in coordinating circadian rhythms, contributing to the overall regulation of this biological timing mechanism.

Simplified