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Spotlight on post-transcriptional control in the circadian system
Post-transcriptional control in the body’s internal clock system
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Abstract
Circadian clocks regulate a significant portion of the genome to synchronize physiology and behavior with environmental cues.
- The circadian clock functions as a self-sustained oscillator, primarily driven by feedback loops and modifications of clock proteins.
- Regulation at the RNA level may significantly influence the circadian transcriptome and proteome.
- RNA-binding proteins are involved in modulating the timing of pre-mRNA processing events, affecting rhythmic expression.
- MicroRNAs could play a role in coordinating circadian rhythms, contributing to the overall regulation of this biological timing mechanism.
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