Phytomedicine : international journal of phytotherapy and phytopharmacology

Pterostilbene may restore the body’s internal clock by targeting a key molecular regulator and protect against metabolism problems caused by lack of sleep

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Pterostilbene (PTE) significantly improved abnormal glucose and lipid metabolism in sleep-restricted mice (p < 0.05).

  • PTE enhanced circadian behavior and rescued circadian rhythm oscillation of liver clock and metabolic output genes in sleep-restricted conditions (p < 0.05).
  • Molecular docking analyses suggest that PTE may interact with specific receptors involved in circadian regulation.
  • PTE increased the activity of a gene promoter linked to circadian rhythms when combined with certain co-factors (p < 0.05).
  • These findings indicate that PTE could influence metabolic health by modulating circadian rhythms disrupted by sleep restriction.

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Competing interests

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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