Pterostilbene targets the molecular oscillator RORγ to restore circadian rhythm oscillation and protect against sleep restriction induced metabolic disorders

Jan 31, 2024Phytomedicine : international journal of phytotherapy and phytopharmacology

Pterostilbene may restore the body’s internal clock by targeting a key molecular regulator and protect against metabolism problems caused by lack of sleep

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Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Pterostilbene (PTE) significantly improved abnormal glucose and lipid metabolism in sleep-restricted mice (p < 0.05).

  • PTE enhanced circadian behavior and rescued circadian rhythm oscillation of liver clock and metabolic output genes in sleep-restricted conditions (p < 0.05).
  • Molecular docking analyses suggest that PTE may interact with specific receptors involved in circadian regulation.
  • PTE increased the activity of a gene promoter linked to circadian rhythms when combined with certain co-factors (p < 0.05).
  • These findings indicate that PTE could influence metabolic health by modulating circadian rhythms disrupted by sleep restriction.

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