Pulmonary aspiration during upper endoscopy in a patient prescribed semaglutide

No SJR dataOct 18, 2024Revista espanola de enfermedades digestivas

Lung choking risk during upper digestive tract exam in a patient taking semaglutide

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Abstract

A case of pulmonary aspiration occurred during upper endoscopy in a patient prescribed semaglutide, a type of glucagon-like peptide-1 receptor agonist (GLP-1RA).

GLP-1 receptor agonists are increasingly used for managing type 2 diabetes and obesity.
There are concerns regarding gastric emptying delays caused by GLP-1RAs, which may lead to gastric food retention.
Observational studies suggest an increased incidence of gastric food retention in patients using long-acting GLP-1RAs like semaglutide.
The relationship between GLP-1RAs and pneumonia aspiration during endoscopy is not well established.
This report presents a specific instance of pulmonary aspiration linked to semaglutide use.

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The past decade has witnessed an increasing use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) owing to robust evidence of its benefits in type 2 diabetes and obesity. However, delay gastric emptying effect of GLP-1RAs has raised concerns for risk of gastric food retention and pneumonia aspiration during upper endoscopy. There have been observation studies reporting an increased incidence of gastric food retention among patients on GLP-1RAs, especially long-acting one like semaglutide. But the association between GLP-1RAs use and pneumonia aspiration during EGD remains unclear due to lack of high-level evidence. We report a case of pulmonary aspiration during EGD in a patient prescribed semaglutide.

Abstract

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