Pupillary Light Reflex Reveals Melanopsin System Alteration in the Background of Myopia-26, the Female Limited Form of Early-Onset High Myopia

Jul 3, 2024Investigative ophthalmology & visual science

Changes in Light-Induced Pupil Response Reveal Altered Melanopsin System in Female-Limited Early-Onset High Myopia

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

Pupil constriction to red light was slightly reduced in patients with myopia (P = 0.02).

Dark-adapted pupil diameter was similar across all participant groups.
The (PIPR) to blue light was significantly weaker (P < 0.01) in female patients with the MYP-26 mutation.
PIPR was normal in myopic controls and an asymptomatic male carrier.
Abnormalities in L/M-cones due to the ARR3 gene mutation may contribute to pathological eye growth in MYP-26.
Malfunction of the melanopsin system in certain retinal cells is associated with symptomatic MYP-26 patients.

AI simplified

PURPOSE: The purpose of this study was to evaluate (PLR) to chromatic flashes in patients with early-onset high-myopia (eoHM) without (myopic controls = M-CTRL) and with (female-limited myopia-26 = MYP-26) genetic mutations in the ARR3 gene encoding the cone arrestin.

METHODS: Participants were 26 female subjects divided into 3 groups: emmetropic controls (E-CTRL, N = 12, mean age = 28.6 ± 7.8 years) and 2 myopic (M-CTRL, N = 7, mean age = 25.7 ± 11.5 years and MYP-26, N = 7, mean age = 28.3 ± 15.4 years) groups. In addition, one hemizygous carrier and one control male subject were examined. Direct PLRs were recorded after 10-minute dark adaptation. Stimuli were 1-second red (peak wavelength = 621 nm) and blue (peak wavelength = 470 nm) flashes at photopic luminance of 250 cd/m². A 2-minute interval between the flashes was introduced. Baseline pupil diameter (BPD), peak pupil constriction (PPC), and (PIPR) were extracted from the PLR. Group comparisons were performed with ANOVAs.

RESULTS: Dark-adapted BPD was comparable among the groups, whereas PPC to the red light was slightly reduced in patients with myopia (P = 0.02). PIPR at 6 seconds elicited by the blue flash was significantly weaker (P < 0.01) in female patients with MYP-26, whereas it was normal in the M-CTRL group and the asymptomatic male carrier.

CONCLUSIONS: L/M-cone abnormalities due to ARR3 gene mutation is currently claimed to underlie the pathological eye growth in MYP-26. Our results suggest that malfunction of the melanopsin system of intrinsically photosensitive retinal ganglion cells (ipRGCs) is specific to patients with symptomatic MYP-26, and may therefore play an additional role in the pathological eye growth of MYP-26.

Key numbers

0.54 ± 0.05

Decrease in PPC

PPC to red flash in MYP-26 group

0.42 ± 0.07

Reduced PIPR6

PIPR6 to blue flash in MYP-26 group

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text ↗

Pupillary Light Reflex Reveals Melanopsin System Alteration in the Background of Myopia-26, the Female Limited Form of Early-Onset High Myopia

Abstract

Key numbers

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Key numbers

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief