The Relation Between Light-Induced Lacrimation and the Melanopsin-Driven Postillumination Pupil Response

Lacrimation in response to 10 to 400 cd/m2 blue light significantly increased compared to baseline.

• Lacrimation increased monotonically with higher intensities of blue light.
• Red light did not produce significant reflex lacrimation until reaching 400 cd/m2.
• A positive linear correlation (r = 0.74, P < 0.001) was observed between the postillumination pupil response and blue light-induced lacrimation.
• No significant correlation was found between red light-induced lacrimation and the postillumination pupil response (r = 0.13, P = 0.25).
• The findings suggest that light-induced reflex lacrimation may be primarily mediated by melanopsin photoactivity.

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