The absence of attenuating effect of red light exposure on pre-existing melanopsin-driven post-illumination pupil response

Pupil responses to blue light exposure did not differ significantly when followed by red light exposure.

• Pupillary light responses were measured in 10 visually normal subjects using both blue light and blue plus red light stimuli.
• In two experiments, red light exposure did not significantly affect the post-illumination pupil response (PIPR) induced by blue light.
• The PIPR for 'Blue+Red' conditions was statistically similar to that of 'Blue Only' conditions, with p-values of 0.55 and 0.38 in the respective experiments.
• These results do not support the idea that red light can reverse the activation of melanopsin after exposure to blue light.
• Findings suggest that the wavelengths responsible for activating and recovering melanopsin may be similar.

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