BMJ open diabetes research & care

Once-weekly semaglutide use in type 2 diabetes patients: combined results by patient characteristics from four real-world studies

Updated

Abstract

In a pooled analysis of 1,212 patients, glycated hemoglobin (HbA) decreased by 1.1% and body weight (BW) by 4.7 kg after 30 weeks of once-weekly semaglutide treatment.

  • Significant reductions in HbA and BW were observed across all baseline subgroups, indicating broad efficacy.
  • Patients who were GLP-1RA-naïve experienced larger reductions in both HbA and BW compared to those who switched from another GLP-1RA.
  • Higher baseline HbA levels were associated with greater reductions in HbA after treatment.
  • At the end of the study, 52.6% of patients achieved HbA levels below 7%.
  • No new safety concerns were reported in the completed studies.

Simplified

Key numbers

-1.1% point
HbA Reduction
Change from baseline to EOS across all subgroups
-4.7 kg
Body Weight Reduction
Change from baseline to EOS across all subgroups
531 of 1012
Patients Achieving HbA <7%
At EOS in the overall pooled population

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Funding

Competing interests

Competing interests: J-FY reports receiving grants from Novo Nordisk during the conduct of the study; grants and personal fees from Novo Nordisk, Eli Lilly, Boehringer Ingelheim, Merck, Janssen, AstraZeneca, and Sanofi, all outside the submitted work. UB reports personal fees for participation in a scientific advisory board from Novo Nordisk, outside the submitted work. A-MC, AC and UE are employees of Novo Nordisk, and A-MC and UE own stock in the company. SC reports consultancy payment for Novo Nordisk (paid to his employer). NRE reports payment for lecturing and reimbursement for participation in scientific advisory boards from Novo Nordisk (paid to her employer), outside the submitted work. PH reports personal fees from AstraZeneca, Eli Lilly, and Novo Nordisk, outside the submitted work. STK reports grants and personal fees for lectures and/or consultancy from AstraZeneca, Boehringer Ingelheim, and Novo Nordisk, and personal fees for lectures and/or consultancy from MSD, Mundipharma and Sanofi, outside of the submitted work. JL reports compensation for clinical trial research, personal fees from continuing medical education events, outside the submitted work. TS reports grants from Abbott and Novo Nordisk outside the submitted work. BS reports fees for advisory board meetings and lectures from Novo Nordisk. GR reports research funding from Novo Nordisk.
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