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Reciprocal regulation of chaperone-mediated autophagy and the circadian clock
Mutual influence between cell cleanup processes and the body's internal clock
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Abstract
Disruption of chaperone-mediated autophagy (CMA) causes changes in circadian rhythms, leading to temporal shifts and altered amplitude in clock-dependent transcription.
- CMA is involved in the rhythmic removal of proteins related to the circadian clock, indicating a functional relationship between these systems.
- In vivo disruption of CMA alters the regular patterns of circadian transcription, similar to changes seen in sleep disorders and ageing.
- Loss of circadian rhythm affects the rhythmicity of CMA, resulting in significant alterations to the cellular protein landscape.
- The interaction between the circadian clock and CMA may contribute to the decline in cellular function associated with ageing and proteostasis issues.
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