Redox regulation of circadian molecular clock in chronic airway diseases

Circadian timing disruption in airway cells may enhance oxidative stress and impair lung function.

• Circadian rhythms in lung function are influenced by the molecular clock, which includes clock genes and their interactions.
• Daily variations in susceptibility to airborne pollutants and chronic airway disease exacerbations are linked to the circadian timing system.
• The circadian molecular clock interacts with redox signaling, impacting responses to oxidative stress.
• Disruption of circadian rhythms in the lungs can lead to increased oxidative stress from pollutants and contribute to lung damage.
• Altered circadian timing may be associated with enhanced inflammation, DNA damage, and fibrosis in lung diseases.
• Clock genes could serve as potential biomarkers and therapeutic targets for chronic lung diseases.

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