REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease

Nov 5, 2013Journal of neurology, neurosurgery, and psychiatry

REM sleep behavior disorder linked to lower quality of life and more non-movement symptoms in early Parkinson’s disease

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

The overall frequency of probable REM sleep behavior disorder (pRBD) in early Parkinson's disease (PD) was 47.2%.

pRBD is frequently observed in patients with PD within 3.5 years of diagnosis.
Patients with pRBD reported more issues with motor aspects of daily living despite similar scores on objective motor scales.
pRBD is associated with greater sleepiness, depression, and cognitive impairment, after adjusting for factors like age and disease duration.
None of the patients had a prior diagnosis of RBD, indicating it may often go unrecognized.

AI simplified

BACKGROUND: Concomitant REM sleep behaviour disorder (RBD) is commonly observed in patients with Parkinson's disease (PD). Although the brainstem structures responsible for the symptoms of RBD correspond to the premotor stages of PD, the association of RBD with motor and non-motor features in early PD remains unclear.

METHODS: The study evaluated 475 patients with PD within 3.5 years of diagnosis for the presence of probable RBD (pRBD) using the REM Sleep Behaviour Disorder Screening Questionnaire (RBDSQ). A neurologist and a trained research nurse carried out evaluation of each participant blinded to the results of the RBDSQ. Standardised rating scales for motor and non-motor features of PD, as well as health-related quality of life measures, were assessed. Multiple linear and logistic regression analyses were used to determine the relationship between pRBD and a variety of outcomes, controlling for confounding factors.

RESULTS: The overall frequency of pRBD was 47.2% (95% CI 42.7% to 51.9%). None of the patients had a previous diagnosis of RBD. Patients with PD and concomitant pRBD did not differ on motor phenotype and scored comparably on the objective motor scales, but reported problems with motor aspects of daily living more frequently. Adjusted for age, sex, disease duration and smoking history, pRBD was associated with greater sleepiness (p=0.001), depression (p=0.001) and cognitive impairment (p=0.006).

CONCLUSIONS: pRBD is common and under-recognised in early PD. It is associated with increased severity and frequency of non-motor features, poorer subjective motor performance and a greater impact on health-related quality of life.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text ↗

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief