Renal function is associated with plasma trimethylamine-N-oxide, choline, l-carnitine and betaine: a pilot study

The combination of four metabolites—TMAO, choline, L-carnitine, and betaine—achieved an AUC of 0.96 in distinguishing chronic kidney disease (CKD) from healthy controls.

• Plasma levels of TMAO, choline, betaine, and L-carnitine showed different correlations with estimated glomerular filtration rate (eGFR).
• These four metabolites were independently linked to CKD after accounting for multiple traditional risk factors.
• The combined metabolite profile effectively differentiated between low and high eGFR in CKD patients.
• The findings suggest that this metabolite combination may assist in evaluating kidney function in CKD.

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