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The RNA helicase FRH is an ATP-dependent regulator of CK1a in the circadian clock of Neurospora crassa
The RNA helicase FRH uses energy to control the CK1a protein in the daily clock of Neurospora crassa
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Abstract
The ATPase activity of FRH influences the hyperphosphorylation of the clock protein FRQ.
- FRQ undergoes hyperphosphorylation and eventual degradation over a circadian period.
- Timed hyperphosphorylation of FRQ is essential for maintaining the circadian clock's timing.
- CK1a-mediated hyperphosphorylation of FRQ is affected by the ATPase activity of FRH.
- The recruitment of CK1a to FRQ for phosphorylation is site-specific and requires activation upon binding.
- CK1a's affinity for FRQ decreases as FRQ becomes more hyperphosphorylated, indicating a potential inactivation of FRQ.
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