Full text is available at the source.
SARS‐CoV‐2 and Mitochondrial Proteins in Neural‐Derived Exosomes of COVID‐19
SARS-CoV-2 and Mitochondrial Proteins Found in Brain Cell Tiny Particles of COVID-19 Patients
AI simplified
Abstract
Mean levels of SARS-CoV-2 N protein were higher in post-acute sequelae of SARS-CoV-2 (PASC) patients with neuropsychiatric manifestations compared to those without.
- SARS-CoV-2 S1 and nucleocapsid proteins were elevated in all PASC sub-groups compared to healthy controls.
- Subunit 6 of mitochondrial respiratory chain complex I and subunit 10 of complex III levels were significantly lower in PASC with neuropsychiatric manifestations.
- Neuroprotective mitochondrial proteins Humanin and MOTS-c showed decreased levels in PASC with neuropsychiatric manifestations compared to controls.
- Levels of voltage-dependent anion-selective channel protein 1 and N-methyl-D-aspartate receptor 1 were reduced in both PASC groups.
- Calcium channel proteins were decreased only in PASC patients with neuropsychiatric manifestations.
AI simplified