Alzheimer's & dementia (New York, N. Y.)

Safety of semaglutide for treating Alzheimer's disease in adults aged 65 and older

Updated

Abstract

The analysis included 3529 participants aged 65 years and older.

  • (AEs) with semaglutide occurred in 73.6% to 92.4% of participants aged 65 and older.
  • AEs leading to permanent discontinuation were more frequent in older participants (9.3%-12.4%) compared to the overall population (5.7%-8.7%).
  • Gastrointestinal disorders were the most frequently reported AEs in older participants (44.6%-73.8%) and the overall population (39.1%-73.4%).
  • Participants aged 65 years and older receiving semaglutide experienced an estimated weight loss of 3.8% at week 52, compared to 0.1% with placebo.
  • Age 65 years and older did not appear to affect the safety considerations of semaglutide.

Simplified

Key numbers

73.6% to 92.4%
Rate
Proportion of participants aged ≥ 65 years reporting with semaglutide.
3.8%
Weight Loss with Semaglutide
Estimated weight loss at week 52 in participants aged ≥ 65 years receiving semaglutide.

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Funding

Competing interests

Marwan Sabbagh reports consulting for Corium, Eisai, Eli Lilly, KeifeRx, NeuroTherapia, Novo Nordisk, Prothena, Roche–Genentech, Signant Health, Synaptogenix, and T3D. Cristina Boschini, Magnus Fugger, Sune Dandanell, and Luis Rafael Solís Tarazona are employees and/or shareholders of Novo Nordisk A/S. Sharon Cohen is an employee of the Toronto Memory Program and has no financial conflicts of interest. Frank Jessen reports fees for advice and presentations for AC Immune, Biogen, Danone/Nutricia, Eisai, Grifols, Eli Lilly, Janssen, Novo Nordisk, and Roche; funding from BMBF, BZGA, DFG, DZNE, Era‐net Neuron, Horizon 2020, IMI, Innovationsfonds (GBA), and JPND; memberships for the German Association of Psychiatry (DGPPN, member of the board), German Association of Biological Psychiatry (DGBP), German Psychogeriatric Association (DGGPP), German Memory Clinic Network (DNG, Chair), and European Alzheimer‘s Disease Consortium (EADC, Chair); and served on the scientific advisory boards for German Alzheimer Association, Alzheimer Europe, and Hirnliga. Sue D. Pedersen reports consulting fees or speaking honoraria from Abbott, AstraZeneca, Bausch, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, HLS, Janssen, Merck, Novo Nordisk, Pfizer, and Sanofi; and research studies for AstraZeneca, Boehringer Ingelheim, Eli Lilly, Medpace, and Novo Nordisk. Vanita R. Aroda reports grants and other from Applied Therapeutics, grants and other from Corcept, grants and other from Fractyl, other from Mediflix, grants and other from Novo Nordisk, other from Pfizer, grants and other from Sanofi, grants from Eli Lilly, and other from Janssen (spouse) outside the submitted work. Author disclosures are available in the supporting information.
PubMed

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