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Abstract
Systemic administration of the GLP-1R agonist liraglutide decreased alcohol intake by reducing dopamine release in the nucleus accumbens.
- GLP-1R signaling in the dorsal lateral septum (dLS) is linked to regulation of alcohol consumption.
- Liraglutide decreased dopamine release in response to ethanol exposure.
- Alcohol consumption was associated with suppressed activity of dLS neurons.
- Liraglutide prevented alcohol-induced suppression of calcium signals in dLS neurons.
- Inactivation of dLS neurons led to increased alcohol consumption and negated the effects of liraglutide.
- Local inhibitory projections from dLS neurons to specific neurons in the ventral lateral septum were identified as important in regulating alcohol intake.
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