Effects of short-term graded dietary carbohydrate intake on intramuscular and whole body metabolism during moderate-intensity exercise

May 27, 2021Journal of applied physiology (Bethesda, Md. : 1985)

How short-term changes in carbohydrate intake affect muscle and whole-body metabolism during moderate exercise

AI simplified

Abstract

Preexercise muscle glycogen content was 54.3 ± 26.4 mmol·kgwet weight in the low carbohydrate diet group.

Lower carbohydrate intake (∼2.4 g CHO·kg·day) resulted in decreased muscle glycogen compared to moderate (∼5.0 g CHO·kg·day) and high (∼6.5 g CHO·kg·day) intakes.
During exercise, lower carbohydrate intake was associated with increased fat metabolism and decreased carbohydrate metabolism as indicated by a lower respiratory exchange ratio (RER: 0.81).
Higher carbohydrate diets led to less pronounced changes in muscle glycogen availability and metabolic responses compared to significant reductions in carbohydrate intake.
Muscle gene expression related to fat utilization was higher in the low carbohydrate diet group.

AI simplified

Altering dietary carbohydrate (CHO) intake modulates fuel utilization during exercise. However, there has been no systematic evaluation of metabolic responses to graded changes in short-term (< 1 wk) dietary CHO intake. Thirteen active men performed interval running exercise combined with isocaloric diets over 3 days before evaluation of metabolic responses to 60-min running at 65% V̇Oon three occasions. Diets contained lower [LOW, 2.40 ± 0.66 g CHO·kg·day, 21.3 ± 0.5% of energy intake (EI)], moderate (MOD, 4.98 ± 1.31 g CHO·kg·day, 46.3 ± 0.7% EI), or higher (HIGH, 6.48 ± 1.56 g CHO·kg·day, 60.5 ± 1.6% EI) CHO. Preexercise muscle glycogen content was lower in LOW [54.3 ± 26.4 mmol·kgwet weight (ww)] compared with MOD (82.6 ± 18.8 mmol·kgww) and HIGH (80.4 ± 26.0 mmol·kgww,< 0.001; MOD vs. HIGH,= 0.85). Whole body substrate oxidation, systemic responses, and muscle substrate utilization during exercise indicated increased fat and decreased CHO metabolism in LOW [respiratory exchange ratio (RER): 0.81 ± 0.01] compared with MOD (RER 0.86 ± 0.01,= 0.0005) and HIGH (RER: 0.88 ± 0.01,< 0.0001; MOD vs. HIGH,= 0.14). Higher basal muscle expression of genes encoding proteins implicated in fat utilization was observed in LOW. In conclusion, muscle glycogen availability and subsequent metabolic responses to exercise were resistant to increases in dietary CHO intake from ∼5.0 to ∼6.5 g CHO·kg·day(46% to 61% EI), while muscle glycogen, gene expression, and metabolic responses were sensitive to more marked reductions in CHO intake (∼2.4 g CHO·kg·day, ∼21% EI).The data presented here suggest that metabolic responses to steady-state aerobic exercise are somewhat resistant to short-term changes in dietary carbohydrate (CHO) intake within the 5-6.5 g CHO·kg·day[46-61% energy intake (EI)] range. In contrast, reduction in short-term dietary CHO intake to ∼2.4 g CHO·kg·day(21% EI) evoked clear changes indicative of increased fat and decreased CHO metabolism during exercise. 2max -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1P P P P P NEW & NOTEWORTHY

Full Text

Full text is available at the source.

View full text ↗

Abstract

Full Text

Related papers

what lands in your inbox each week: