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Abstract
Skin aging involves a combination of intrinsic and extrinsic factors that lead to a decline in skin function and structure.
- Skin aging is marked by epigenetic changes that disrupt normal gene expression and promote cellular aging.
- Cellular senescence and changes in mitochondria play significant roles in the aging process of the skin.
- Immunosenescence, or the failure to clear senescent cells, contributes to chronic inflammation in the skin.
- This inflammation leads to increased production of signaling molecules, changes in the skin's structural components, and ongoing tissue damage.
- Potential interventions targeting these mechanisms include therapies aimed at epigenetic and mitochondrial functions, as well as immune modulation.
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