Relationship between sleep characteristics and aortic aneurysm/dissection: a two-sample Mendelian randomisation study

Jul 14, 2025BMJ open

Links between sleep patterns and risk of aortic bulges or tears using genetic analysis

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Abstract

No genetic evidence supports a causal relationship between sleep characteristics and aortic aneurysm and dissection ().

Seven sleep-related traits were analyzed, including sleep duration, morning wake time, and insomnia.
No significant causal links were found between these sleep traits and aortic aneurysm or dissection.
The odds ratios for the sleep traits ranged from 0.759 to 1.280, with p-values indicating no statistical significance.
Results were confirmed through various sensitivity analyses, showing robustness and reliability.
Further large-scale randomized controlled trials are needed to explore potential causal relationships.

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OBJECTIVE: The causal relationship between sleep characteristics and aortic aneurysm and dissection () is little known.

METHODS: In this two-sample (MR) study, we selected seven sleep-related traits (sleep duration, getting up in the morning, chronotype, nap during day, insomnia, snoring, and narcolepsy) from published genome-wide association study (GWAS)-related genetic variants as instrumental variables. Causality was assessed by two-sample MR analysis using inverse-variance weighting (IVW), MR-Egger regression, weighted median, weighted mode and simple model. Horizontal pleiotropy was tested using MR-Egger regression and MR-polytropic residuals and outliers, and heterogeneity was calculated by Cochran's Q test.

RESULTS: There was no evidence of causality among sleep duration (IVW: OR=0.759, 95% CI: 0.489 to 1.177, p=0.218), getting up in the morning (IVW: OR=1.148, 95% CI: 0.768 to 1.716, p=0.502), chronotype (IVW: OR=0.960, 95% CI: 0.796 to 1.158, p=0.670), nap during day (IVW: OR=1.248, 95% CI: 0.771 to 2.020, p=0.367), sleeplessness/insomnia (IVW: OR=1.280, 95% CI: 0.678 to 2.414, p=0.447), snoring (IVW: OR=0.963, 95% CI: 0.770 to 1.203, p=0.738), narcolepsy (IVW: OR=1.025, 95% CI: 0.367 to 2.863, p=0.962) and aortic aneurysm. Moreover, there was no evidence to suggest a causal relationship among sleep traits and abdominal aneurysm, thoracic aneurysm and aortic dissection. Sensitivity analyses, including leave-one-out, horizontal pleiotropy and heterogeneity tests, indicated that our results were robust and reliable.

CONCLUSIONS: Overall, our study found no genetic evidence of a causal relationship between sleep characteristics and AAD. Large-scale randomised controlled trial experiments are also needed to further verify the causal relationship between sleep and AAD.

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Relationship between sleep characteristics and aortic aneurysm/dissection: a two-sample Mendelian randomisation study

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