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Abstract
Sleep disorders may disrupt the proteostasis network, which is essential for maintaining cellular functions.
- A bidirectional relationship exists between sleep disorders and molecular mechanisms involved in protein homeostasis.
- Dysfunction of the proteostasis network is associated with various sleep disorders, including insomnia and sleep-disordered breathing.
- Imbalances in the proteostasis network due to sleep disruption may contribute to chronic diseases such as neurodegenerative and metabolic disorders.
- Sleep disturbances could act as modifiers of the proteostasis network, influencing susceptibility to age-related diseases.
- The review emphasizes the necessity for longitudinal studies to explore the relationships among sleep, proteostasis, and aging.
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