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Sleep–wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex
How Sleep, Wakefulness, and Internal Clocks Affect Daily Gene Activity and DNA Accessibility in the Mouse Thinking Areas
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Abstract
A 6-hour in mice led to long-term changes in gene expression dynamics.
- The interaction between sleep-wake processes and circadian rhythms influences gene regulation.
- Rhythmic genes are primarily regulated by homeostatic processes, with some opposition from circadian control.
- Sleep deprivation resulted in damped oscillations of core clock genes, indicating a direct impact on the molecular clock.
- was highly dynamic during sleep deprivation, affecting gene expression.
- Changes in gene expression are linked to the accessibility of enhancers and repressors rather than just promoters.
- Serum response factor (SRF) was identified as a key regulator reflecting sleep pressure changes.
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Key numbers
1,793
Differentially Accessible Peaks During
Number of chromatin peaks differentially accessible at ZT3 after 3 hours of .
2,098
Differentially Accessible Peaks at End of
Number of peaks differentially accessible at ZT6 after 6 hours of .
210
Genes with Long-Term Differential Expression
Number of genes differentially expressed after recovery from .