Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Kinase inhibitors may modulate the circadian clock, which regulates 24-hour rhythms crucial for various physiological processes.

• The circadian clock operates through a feedback loop involving transcription and translation, where phosphorylation is essential for maintaining rhythms.
• Dysregulation of the circadian clock is implicated in numerous diseases.
• Promising targets for modulating the circadian clock include various kinase inhibitors.
• There is a critical discrepancy between the activity of inhibitors observed in lab studies and their effectiveness in living organisms.
• Rigorous in vivo validation is necessary to translate the therapeutic potential of kinase inhibitors into effective treatments for circadian-related disorders.

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