Circadian clock genes: Potential therapeutic targets for autoimmune diseases

Circadian rhythm disruption is a significant risk factor for immune dysregulation.

• The core clock genes, including CLOCK, BMAL1, PER, and CRY, regulate physiological processes linked to circadian rhythms.
• Disruption of circadian rhythms may contribute to autoimmune diseases by affecting immune system regulation.
• The review highlights the importance of clock genes in the differentiation and function of immune cells, particularly Th17 cells.
• Small molecule modulators targeting clock genes and non-pharmacological interventions like sleep regulation and intermittent fasting are discussed as potential therapies.
• The findings suggest that maintaining circadian rhythm balance could lead to new treatment strategies for autoimmune diseases.

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