Full text is available at the source.
Abstract
Total weight loss of 58.8% (-108.7 kg) was achieved in a patient with Prader-Willi syndrome after 18 months of treatment.
- The individual had a starting weight of 185 kg and a BMI of 59.7 kg/m².
- Initially diagnosed with type 2 diabetes, the patient's glycated hemoglobin decreased from 8.3% to 4.9%, indicating potential diabetes remission.
- Treatment included sequential incretin-based therapy combined with a structured hypocaloric diet and supervised exercise.
- Mild transient gastrointestinal symptoms were reported during medication dose escalation, but no serious adverse events occurred.
- Post-treatment bioimpedance indicated a skeletal muscle mass of 38.5 kg after significant weight loss.
Simplified