Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World

The circadian clock influences gene regulation across multiple layers in mammals.

• The master clock in the brain synchronizes the body's internal rhythms with external light and dark cycles.
• Molecular clocks are present in nearly all cells, indicating a widespread influence on physiological processes.
• Recent investigations show that the circadian clock affects gene regulation from chromatin structure to protein levels.
• Understanding these connections could enhance knowledge of how timing cues operate at cellular and tissue levels.

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