Full text is available at the source.
Advances in T Cell-Based Cancer Immunotherapy: From Fundamental Mechanisms to Clinical Prospects
Progress in T Cell Cancer Immunotherapy: From Basic Understanding to Treatment Potential
AI simplified
Abstract
T cell function and quantity decline with age, impacting antitumor immunity.
- Immunosenescence is characterized by reduced T cell functionality and numbers as individuals age.
- T cell maturation mechanisms and their role in antitumor responses are examined.
- Thymic involution may affect T cell diversity and cancer prognosis.
- Recent advances in adoptive T cell therapies include tumor-infiltrating lymphocyte therapy, engineered T cell receptor therapy, and CAR-T therapy.
- DNA-encoded library technologies are being utilized for high-throughput screening of TCR-antigen interactions, aiding in the discovery of new tumor antigens.
- Strategies to enhance T cell therapy efficacy are being explored to address challenges within the solid tumor microenvironment.
AI simplified